The Peptide Revolution: What You Need to Know About GLP-3, “Wolverine Peptides,” and Tesamorelin

Peptide science is advancing at a rapid pace, and several compounds are attracting major attention—from lesser-known incretin hormones to regenerative “Wolverine” peptides and clinically established growth-hormone analogues. In this post, we explore GLP-3, BPC-157, TB-500, and tesamorelin to help you understand why researchers, clinicians, and wellness enthusiasts are watching these peptides so closely.

GLP-3: The Under-Explored Member of the Incretin Family

Most people are familiar with GLP-1 due to its role in today’s metabolic-health medications, and GLP-2 is known for its involvement in gut integrity. But GLP-3, another peptide derived from proglucagon, is only beginning to get attention.

What Is GLP-3?

GLP-3 is structurally related to GLP-1 and GLP-2, yet its biological roles are less clearly defined. Early research suggests possible involvement in:

• Gut-brain communication

• Nutrient and digestive signaling

• Neuroendocrine pathways

As interest in incretin biology grows, GLP-3 is emerging as a potential piece of the metabolic puzzle. This peptide should be approved by the FDA by 2026 and we are excited to integrate it into our practice at AW&H!

BPC-157 & TB-500: The “Wolverine Peptides” of Regenerative Biology

Few peptides have sparked as much public curiosity as BPC-157 and TB-500. Nicknamed the “Wolverine peptides,” they’re frequently discussed in regenerative-science circles due to their potential involvement in tissue-repair pathways observed in preclinical research.

BPC-157: A Synthetic Peptide Inspired by the GI Tract

BPC-157 is based on a natural gastric peptide and has been studied in animal models for its potential effects on:

• Angiogenesis (new blood vessel formation)

• Tissue-repair signaling

• Gastrointestinal tissue health

TB-500: A Fragment of Thymosin Beta-4

TB-500 originates from a portion of thymosin beta-4, a protein connected to cell movement and structural organization. Some of the preclinical research highlights its potential involvement in:

• Cell migration

• Wound-healing processes

• Soft-tissue repair pathways

Important Note on Research Status

Neither peptide is FDA-approved, and most findings come from animal or cell-based studies. Their mechanisms, safety profiles, and potential human applications remain active subjects of investigation.

Tesamorelin: A GHRH Analogue With a Defined Clinical Role

Unlike many research peptides, tesamorelin holds FDA approval—but only for reducing excess abdominal fat in individuals with HIV-related lipodystrophy. Still, it’s gaining broader attention in scientific communities.

Why Researchers Are Interested

Tesamorelin—a synthetic form of growth hormone-releasing hormone—is being explored for its potential effects on:

• Growth-hormone signaling

• Visceral fat metabolism

• Cognitive and neuroprotective pathways

• Body-composition dynamics

While its approved use is specific, ongoing studies continue to reveal new areas worth watching.